Persistent cold pools form as layers of cold stagnant air within topographical depressions mainly during wintertime when the near-surface air cools and/or the air aloft warms and daytime surface heating is insufficient to mix out the stable layer. An area often affected by persistent cold pools is the Columbia River Basin in the Pacific Northwest, when a high-pressure system east of the Cascade Range promotes radiative cooling and easterly flow. The only major outflow for the easterly flow is through the narrow Columbia River Gorge which cuts through the north-south oriented Cascade Range and often experiences very strong gap flows. Observations collected during the Second Wind Forecast Improvement Project (WFIP2) are used to study a persistent cold pool in the Columbia River Basin between 10-19 Jan 2017 which was associated with a strong gap flow. We used data from various remote sensing and in situ instruments and a optimal estimation physical retrieval to obtain thermodynamic profiles to address the temporal and spatial characteristics of the cold pool and gap flow and to investigate the physical processes involved during formation, maintenance and decay. While large-scale temperature advection occurred during all phases, we found that the cold pool vertical structure was modulated by the existence of low-level clouds and that turbulent shear-induced mixing and downslope wind storms likely played a role during its decay.